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Pharmacologic Alternatives to BZRAs

The third group of treatments consists of non-benzodiazepine pharmacological agents (note: Not z-drugs, since they have mechanisms of action at the GABA receptor similar to benzodiazepines).  These include:

  • Adrenergic inhibiting agents
  • Mono-amine agents
  • Serotonin receptor agents
  • Anti-psychotic medications
  • Sodium channel blockers
  • Calcium channel modulators
  • Glutamine system agents
  • Hormones
  • Plant-based medicines, including CBD